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DUBAI, United Arab Emirates 鈥� Israel launched blistering attacks on the heart of Iran's nuclear and military structure Friday, deploying warplanes and drones to attack key facilities and kill top generals and scientists聽鈥� a barrage it said was necessary before its adversary got any closer to building an atomic weapon.

Iran retaliated by unleashing scores of ballistic missiles on Israel late Friday, with explosions flaring in the skies over Jerusalem and Tel Aviv.

In a second round of attacks, sirens and a round of explosions, possibly from Israeli interceptors, could be heard booming in the sky over Jerusalem early Saturday and the Israeli military said another attack was taking place.

The Iranian outlet Nour News, which has close links with the paramilitary Revolutionary Guard, said a wave was being launched. Journalists in Tel Aviv could see at least two Iranian missiles hit the ground, but there was no immediate word of casualties.

A hospital in Tel Aviv treated seven people wounded in the second Iranian barrage; all but one had light injuries.

Meanwhile, the sound of explosions and Iranian air defense systems firing at targets echoed across central Tehran shortly after midnight on Saturday, and a reporter could hear air raid sirens near their home.

鈥淲e will not allow them to escape safely from this great crime they committed,鈥� Iran鈥檚 Supreme Leader Ayatollah Ali Khamenei said in a recorded message in which he vowed revenge. Iran鈥檚 U.N. ambassador said 78 people were killed and more than 320 wounded in Israeli attacks.

Israel鈥檚 paramedic services said 34 people were wounded in a barrage on the Tel Aviv area, including a woman who was critically injured after being trapped under rubble.

U.S. ground-based air defense systems in the region helped shoot down Iranian missiles, said a U.S. official who spoke on condition of anonymity.

The developments raised fears of all-out war between the countries and propelled the region, already on edge, into even greater upheaval.

Israel long threatened such a strike, and successive American administrations sought to prevent it, fearing it would ignite a wider conflict across the Middle East and possibly be ineffective at destroying Iran's dispersed and hardened nuclear program.

But a confluence of developments triggered by Hamas' Oct. 7, 2023, attack 鈥� and the reelection of U.S. President Donald Trump 鈥� created the conditions that allowed Israel to finally follow through on its threats. Israeli Prime Minister Benjamin Netanyahu said the U.S. was informed in advance of the attack.

On Thursday, the U.N.鈥檚 atomic watchdog censured Iran for not complying with obligations meant to prevent it from developing a nuclear weapon.

Countries in the region condemned Israel's attack, while leaders around the globe called for immediate deescalation from both sides.

The U.N. Security Council held an emergency meeting Friday afternoon at Iran's request.聽 In a letter to the council, Iran's Foreign Minister Abbas Araghchi called the killing of its officials and scientists "state terrorism" and affirmed his country's right to self-defense.

Israel's military said about 200 aircraft were involved in the initial attack on about 100 targets. Its Mossad spy agency positioned explosive drones and precision weapons inside Iran ahead of time, and used them to target Iranian air defenses and missile launchers near Tehran, according to two security officials who spoke on condition of anonymity.

It was not possible to independently confirm the officials' claims.

Among the key sites Israel attacked was Iran's main nuclear enrichment facility in Natanz. It also appeared to strike a second, smaller nuclear enrichment facility in Fordo, about 60 miles southeast of Tehran, according to an Iranian news outlet close to the government.

Israel said it struck a nuclear research facility in Isfahan, too, and said it destroyed dozens of radar installations and surface-to-air missile launchers in western Iran. Iran confirmed the strike at Isfahan.

Israel military spokesman Brig. Gen. Effie Defrin said the Natanz facility was "significantly damaged" and that the operation was "still in the beginning."

An official said Israel is prepared for an operation that could last up to two weeks but there was no firm timeline.

Among those killed were three of Iran's top military leaders: one who oversaw the entire armed forces, Gen. Mohammad Bagheri; one who led the paramilitary Revolutionary Guard, Gen. Hossein Salami; and the head of the Guard's ballistic missile program, Gen. Amir Ali Hajizadeh.

Iran confirmed all three deaths, significant blows that will complicate efforts to retaliate. Khamenei said other top military officials and scientists were also killed.

Trump urged Iran on Friday to reach a deal with the U.S. on its nuclear program, warning on his social media platform that Israel's attacks "will only get worse."

On Wednesday, the U.S. pulled some American diplomats from Iraq's capital and offered voluntary evacuations for the families of U.S. troops in the wider Middle East.

On Friday, the U.S. began shifting military resources in the region, including ships, as Israel prepared for more retaliation, two U.S. officials said on condition of anonymity.

The Navy directed the destroyer USS Thomas Hudner from the western Mediterranean Sea toward the eastern Mediterranean and directed a second destroyer to begin moving forward so it can be available if requested by the White House.

American fighter jets also are patrolling the sky in the Middle East to protect personnel and installations, and air bases in the region are taking additional security precautions, officials said. The officials spoke on the condition of anonymity to provide details not yet made public or to discuss ongoing operations.

Trump met with his National Security Council principals Friday to discuss the situation.