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The Bills have five prime-time games, beginning Week 1 at home against the Baltimore Ravens, and their bye is Week 7. Here's a game-by-game breakdown, including start times, with the exception of Week 18, and broadcast information:聽

WEEK 1

BALTIMORE

8:20 p.m., Sept. 7, WGRZ

Have your popcorn ready: The final home opener at Highmark Stadium will be a rematch of the AFC divisional playoff game, with two of the NFL鈥檚 best quarterbacks, Josh Allen and Lamar Jackson, leading two of the top teams.

WEEK 2

AT N.Y. JETS

1 p.m., Sept. 14, WIVB

The Jets have generated some buzz this offseason with the arrival of new coach Aaron Glenn and the signing of quarterback Justin Fields, but the Bills have won eight of the past 10 meetings between the AFC East foes.

MIAMI

8:15 p.m., Sept. 18, Amazon

The Dolphins have lost 13 of their last 14 games against the Bills, including an AFC wild-card game in January 2023, and Miami added nothing this offseason to suggest it can contend for the division title.

WEEK 4

NEW ORLEANS

1 p.m., Sept. 28, WIVB

This one could get ugly. The Bills will have 10 days to prepare for first-year coach Kellen Moore鈥檚 Saints, who lost their starting quarterback, Derek Carr, to retirement and did not have the cap space to improve their roster.

WEEK 5

NEW ENGLAND

8:20 p.m., Oct. 5, WGRZ

Patriots first-year coach Mike Vrabel overhauled his roster to strengthen the offensive and defensive lines, and former Bills receiver Stefon Diggs is one of several new receivers added for quarterback Drake Maye.

WEEK 6

AT ATLANTA

7:15 p.m., Oct. 13, ESPN

The Bills鈥� fourth prime-time game in six weeks is their first matchup with Falcons second-year quarterback Michael Penix Jr., and Atlanta will use its rookie pass rushers, first-round picks Jalon Walker and James Pearce Jr., to try to get to Allen.

WEEK 8

AT CAROLINA

1 p.m., Oct. 26, WUTV

The NFL鈥檚 worst defense will have trouble containing Allen and the Bills鈥� offense, though the Panthers鈥� offense should be improved with first-round draft choice Tetairoa McMillan catching passes from quarterback Bryce Young for second-year coach Dave Canales.

WEEK 9

KANSAS CITY

4:25 p.m., Nov. 2, WIVB

A rematch of the AFC championship game will allow the Bills to show in prime time at home how a revamped defense can help them finally slay the giant that is Patrick Mahomes and the Chiefs鈥� offense.

WEEK 10

AT MIAMI

1 p.m., Nov. 9, WIVB

The Bills鈥� two losses to the Dolphins since December 2016 were both on the road at Hard Rock Stadium. Buffalo will need to contain Miami鈥檚 rushing attack, specifically running back聽顿别'痴辞苍听Achane.

WEEK 11

TAMPA BAY

1 p.m., Nov. 16, WIVB

Baker Mayfield added another weapon this offseason with first-round draft pick wide receiver Emeka Egbuka, but the Buccaneers鈥� pass defense was among the NFL鈥檚 worst last season.

WEEK 12

AT HOUSTON

8:15 p.m., Nov. 20, Amazon

Three days between games isn鈥檛 ideal timing for the Bills. Their defense will have a difficult matchup against the Texans, whose quarterback, C.J. Stroud, has three new wide receivers, including Christian Kirk.

WEEK 13

AT PITTSBURGH

4:25 p.m., Nov. 30, WIVB

Will the Steelers have Aaron Rodgers at quarterback, or will Mason Rudolph be throwing to DK Metcalf? The Bills haven鈥檛 played in Pittsburgh since Dec. 15, 2019, when they left with a 17-10 victory.

WEEK 14

CINCINNATI

4:25 p.m., Dec. 7, WUTV

The Bills鈥� secondary will need to shut down 闯补'惭补谤谤听Chase and Tee Higgins, while their defensive line can鈥檛 give Joe Burrow too much time to throw, and Cincinnati used three of its first four draft picks on its defense.

WEEK 15

AT NEW ENGLAND

1 p.m., Dec. 14, WIVB

The Bills鈥� final road game within the division is at Gillette Stadium, where they suffered a disappointing loss in October 2023, and the first matchup should reveal whether the Patriots鈥� offensive line can hold up against Buffalo鈥檚 defensive front.

WEEK 16

AT CLEVELAND

1 p.m., Dec. 21, WIVB

Between the awkward quarterback situation and meddling owner, the Browns deserve a reality television series on Bravo. Could we see Shedeur Sanders as their quarterback against the Bills?

WEEK 17

PHILADELPHIA

4:25 p.m., Dec. 28, WUTV

A meeting with the reigning Super Bowl championships should be the Bills' final tuneup and measuring-stick game before the playoffs. The Eagles will be a popular choice to repeat.

WEEK 18

N.Y. JETS

Date and time TBD

If everything goes according to the Bills鈥� plan, they will have already secured home-field advantage and most of their starters, most notably Allen, will only play a series or two in their final regular-season game at Highmark Stadium.